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1

Comparison of the effects of repeated oral versus subcutaneous fenfluramine administration on rat brain monoamine neurons: Pharmacokinetic and dose-response data

Errol B. De Souza, Robert Zaczek, Steven Culp, Nathan M. Appel, Joseph F. Contrera

Journal:

Pharmacology Biochemistry and Behavior

Year:

1991

Language:

english

File:

PDF, 748 KB

english, 1991

2

Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands

Argyrios G. Arvanitis, Joseph T. Rescinito, Charles R. Arnold, Richard G. Wilde, Gary A. Cain, Jung Hui Sun, Jia-Sheng Yan, Christopher A. Teleha, Lawrence W. Fitzgerald, John McElroy, Robert Zaczek,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 132 KB

english, 2003

3

P4-341 Evidence that γ-secretase mediated notch-1 processing is not regulated by notch cytoplasmic domain sequences

Meredith, Jere, Blat, Yuval, Olson, Richard E., Zaczek, Robert

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 166 KB

english, 2004

4

Methylphenidate and pemoline do not cause depletion of rat brain monoamine markers similar to that observed with methamphetamine

Robert Zaczek, George Battaglia, Joseph F. Contrera, Steven Culp, Errol B. De Souza

Journal:

Toxicology and Applied Pharmacology

Year:

1989

Language:

english

File:

PDF, 663 KB

english, 1989

5

Design, Synthesis, and Biological Evaluation of 1,2,3,7-Tetrahydro-6 H -purin-6-one and 3,7-Dihydro-1 H -purine-2,6-dione Derivatives as Corticotropin-Releasing Factor 1 Receptor Antagonists

Hartz, Richard A., Nanda, Kausik K., Ingalls, Charles L., Ahuja, Vijay T., Molski, Thaddeus F., Zhang, Ge, Wong, Harvey, Peng, Yong, Kelley, Michelle, Lodge, Nicholas J., Zaczek, Robert, Gilligan, Pau

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 211 KB

english, 2004

6

Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

James P. Beck, Argyrios G. Arvanitis, Matt A. Curry, Joseph T. Rescinito, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 300 KB

english, 1999

7

Brain transcription factor gene expression, neurotransmitter levels, and novelty response behaviors: Alterations during rat amphetamine withdrawal and following chronic injection stress

Antonio M. Persico, Charles W. Schindler, Robert Zaczek, Michael T. Brannock, George R. Uhl

Journal:

Year:

1995

Language:

english

File:

PDF, 2.05 MB

english, 1995

8

Corticotropin Releasing Factor (CRF) Receptor Modulators: Progress and Opportunities for New Therapeutic Agents

Gilligan, Paul J., Robertson, David W., Zaczek, Robert

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 622 KB

english, 2000

9

Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

James P. Beck, Matt A. Curry, Robert J. Chorvat, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 219 KB

english, 1999

10

Kirk-Othmer Encyclopedia of Chemical Technology || Memory-Enhancing Drugs

Year:

2000

Language:

english

File:

PDF, 204 KB

english, 2000

11

Effects of linopirdine (DuP 996) and X9121 on age-related memory impairments and on the cholinergic system

Mark G. Baxter, Kenneth W. Rohrbach, S. William Tam, Robert Zaczek, Karyn M. Frick, Stephanie Golski, Rui-Qian Wan, David S. Olton

Journal:

Drug Development Research

Year:

1994

Language:

english

File:

PDF, 936 KB

english, 1994

12

γ-Secretase activity is not involved in presenilin-mediated regulation of β-catenin

Jere E Meredith Jr., Qian Wang, Thomas J Mitchell, Richard E Olson, Robert Zaczek, Andrew M Stern, Dietmar Seiffert

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 281 KB

english, 2002

13

4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2,4-dichlorophenyl)pyrazolo[1,5- a ]-1,3,5-triazine: A Potent, Orally Bioavailable CRF 1 Receptor Antagonist

He, Liqi, Gilligan, Paul J., Zaczek, Robert, Fitzgerald, Lawrence W., McElroy, John, Shen, H-S. L., Saye, Jo Anne, Kalin, Ned H., Shelton, Steven, Christ, David, Trainor, George, Hartig, Paul

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 98 KB

english, 2000

14

ChemInform Abstract: Corticotropin Releasing Factor (CRF) Receptor Modulators: Progress and Opportunities for New Therapeutic Agents

Paul J. Gilligan, David W. Robertson, Robert Zaczek

Journal:

Year:

2000

File:

PDF, 26 KB

2000

15

Linopirdine: Pharmacology of a Neurotransmitter Release Enhancer

Robert Zaczek, Robert J. Chorvat, Barry S. Brown

Journal:

CNS Drug Reviews

Year:

1997

Language:

english

File:

PDF, 890 KB

english, 1997

16

[Part 1: Biological Sciences] || N-acetylaspartylglutamate: An Endogenous Peptide with High Affinity for a Brain ``Glutamate'' Receptor

Robert Zaczek, Kerry Koller, Robert Cotter, David Heller and Joseph T. Coyle

Journal:

Proceedings of the National Academy of Sciences

Year:

1983

Language:

english

File:

PDF, 634 KB

english, 1983

17

Microinjection of kainic acid into the rat hippocampus

Robert Schwarcz, Robert Zaczek, Joseph T. Coyle

Journal:

European Journal of Pharmacology

Year:

1978

Language:

english

File:

PDF, 1.12 MB

english, 1978

18

Cerebrospinal fluid homovanillic acid and parkinsonism in Huntington's disease

Dr. Roger Kurlan, David Goldblatt, Robert Zaczek, Keith Jeffries, Carrie Irvine, Joseptemberh Coyle, Ira Shoulson

Journal:

Annals of Neurology

Year:

1988

Language:

english

File:

PDF, 339 KB

english, 1988

19

ChemInform Abstract: Thiazolo[4,5-d]pyrimidine Thiones and -ones as Corticotropin-Releasing Hormone (CRH-R1) Receptor Antagonists.

James P. Beck, Matt A. Curry, Robert J. Chorvat, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Year:

1999

File:

PDF, 33 KB

1999

20

Unique properties of norepinephrine release from terminals arising from the locus coeruleus: high potassium sensitivity and lack of linopirdine (DuP 996) enhancement

Zaczek, Robert, Tinker, William J., Tam, S.William

Journal:

Neuroscience Letters

Year:

1993

Language:

english

File:

PDF, 431 KB

english, 1993

21

N-methyl-d-aspartic acid: A convulsant with weak neurotoxic properties

Zaczek, Robert, Collins, James, Coyle, Joseph T.

Journal:

Neuroscience Letters

Year:

1981

Language:

english

File:

PDF, 572 KB

english, 1981

22

Role for Brain Corticotropin-Releasing Factor in the Weight-Reducing Effects of Chronic Fenfluramine Treatment in Rats*

APPEL, NATHAN M., OWENS, MICHAEL J., CULP, STEVEN, ZACZEK, ROBERT, CONTRERA, JOSEPH F., BISSETTE, GARTH, NEMEROFF, CHARLES B., DE SOUZA, ERROL B.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.39 MB

english, 1991

23

Local and Distant Neuronal Degeneration Following Intrastriatal Injection of Kainic Acid

ZACZEK, ROBERT, SIMONTON, SUE, COYLE, JOSEPH T.

Journal:

Journal of Neuropathology and Experimental Neurology

Year:

1980

Language:

english

File:

PDF, 1.39 MB

english, 1980

24

ChemInform Abstract: Purin-8-ones as Corticotropin-Releasing Hormone (CRH-R1) Receptor Antagonists.

James P. Beck, Argyrios G. Arvanitis, Matt A. Curry, Joseph T. Rescinito, Larry W. Fitzgerald, Paul J. Gilligan, Robert Zaczek, George L. Trainor

Journal:

Year:

1999

File:

PDF, 30 KB

1999

25

Postsynaptic diacylglycerol lipase α mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex

Hiroki Yoshino, Takeaki Miyamae, Gwenn Hansen, Brian Zambrowicz, Michael Flynn, Donna Pedicord, Yuval Blat, Ryan S. Westphal, Robert Zaczek, David A. Lewis, Guillermo Gonzalez-Burgos

Journal:

The Journal of Physiology

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

26

Long-term sequelae of striatal kainate lesion

Robert Zaczek, Robert Schwarcz, Joseph T. Coyle

Journal:

Year:

1978

Language:

english

File:

PDF, 2.00 MB

english, 1978

27

MK-801 disrupts and nicotine augments 40 Hz auditory steady state responses in the auditory cortex of the urethane-anesthetized rat

Sivarao, Digavalli V., Frenkel, Mikhail, Chen, Ping, Healy, Francine L., Lodge, Nicholas J., Zaczek, Robert

Journal:

Neuropharmacology

Year:

2013

Language:

english

File:

PDF, 1.63 MB

english, 2013

28

The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine: A corticotropin-releasing factor (hCRF1) antagonist

Paul J. Gilligan, Caryn Baldauf, Anthony Cocuzza, Dennis Chidester, Robert Zaczek, Lawrence W. Fitzgerald, John McElroy, Mark A. Smith, H.-S.L. Shen, Jo Anne Saye, David Christ, George Trainor, David

Journal:

Bioorganic & Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 172 KB

english, 2000

29

2-Fluoro-4-pyridinylmethyl Analogues of Linopirdine as Orally Active Acetylcholine Release-Enhancing Agents with Good Efficacy and Duration of Action

Earl, Richard A., Zaczek, Robert, Teleha, Christopher A., Fisher, Barbara N., Maciag, Carla M., Marynowski, Maria E., Logue, Andrew R., Tam, S. William, Tinker, William J., Huang, Shiew-Mei, Chorvat,

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 232 KB

english, 1998

30

γ-Secretase Inhibitors for Alzheimer’s Disease

Dr Donna M. Barten,Jere E. Meredith Jr,Robert Zaczek,John G. Houston…

Journal:

Year:

2006

Language:

english

File:

PDF, 135 KB

english, 2006

31

Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors

Ferkany, John W., Zaczek, Robert, Coyle, Joseph T.

Journal:

Year:

1982

File:

PDF, 406 KB

1982

32

Dopamine transporter: expression in Xenopus oocytes

Uhl, George R., O'Hara, Bruce, Shimada, Shoichi, Zaczek, Robert, DiGiorgianni, Jess, Nishimori, Toshikazu

Journal:

Molecular Brain Research

Year:

1991

Language:

english

File:

PDF, 699 KB

english, 1991

33

Solubilization of High Affinity Corticotropin-Releasing Factor Receptors from Rat Brain: Characterization of an Active Digitonin-Solubilized Receptor Complex

GRIGORIADIS, DIMITRI E., ZACZEK, ROBERT, PEARSALL, DENISE M., SOUZA, ERROL B. DE

Journal:

Year:

1989

Language:

english

File:

PDF, 1.47 MB

english, 1989

34

Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent γ-secretase inhibitors

Michael G. Yang, Jian-Liang Shi, Dilip P. Modi, Jennifer Wells, Brian M. Cochran, Mark A. Wolf, Lorin A. Thompson, Mercy M. Ramanjulu, Arthur H. Roach, Robert Zaczek, David W. Robertson, Ruth R. Wexle

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 209 KB

english, 2007

35

N-Acetyl-Aspartyl-Glutamate: Regional Levels in Rat Brain and the Effects of Brain Lesions as Determined by a New HPLC Method

Kerry J. Koller, Robert Zaczek, Joseph T. Coyle

Journal:

Journal of Neurochemistry

Year:

1984

Language:

english

File:

PDF, 605 KB

english, 1984

36

Effects of anaesthetics and anticonvulsants on the action of kainic acid in the rat hippocampus

Robert Zaczek, Mark F. Nelson, Joseph T. Coyle

Journal:

European Journal of Pharmacology

Year:

1978

Language:

english

File:

PDF, 344 KB

english, 1978

37

Ion channel modulators that enhance acetylcholine release: potential therapies for Alzheimer’s disease

Chorvat, Robert J, Zaczek, Robert, Brown, Barry S

Journal:

Expert Opinion on Investigational Drugs

Year:

1998

Language:

english

File:

PDF, 226 KB

english, 1998

38

Imidazo[4,5-c]pyridines as corticotropin releasing factor receptor ligands

Argyrios G. Arvanitis, Joseph T. Rescinito, Charles R. Arnold, Richard G. Wilde, Lawrence W. Fitzgerald, Robert Zaczek, Paul R. Hartig, Scott Grossman, Stephen P. Arneric, Paul J. Gilligan, Richard E.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 109 KB

english, 2003

39

The Pharmacology of DMP696 and DMP904, Non-Peptidergic CRF1 Receptor Antagonists

Yu-Wen Li, Lawrence Fitzgerald, Harvey Wong, Snjezana Lelas, Ge Zhang, Mark D. Lindner, Tanya Wallace, John McElroy, Nicholas J. Lodge, Paul Gilligan, Robert Zaczek

Journal:

CNS Drug Reviews

Year:

2005

Language:

english

File:

PDF, 227 KB

english, 2005

40

Effects of linopirdine, HP 749, and glycyl-prolyl-glutamate on transmitter release and uptake

Robert Zaczek, William J. Tinker, Andrew R. Logue, Gary A. Cain, Christopher A. Teleha, S. William Tam

Journal:

Drug Development Research

Year:

1993

Language:

english

File:

PDF, 580 KB

english, 1993

41

Intrasynaptosomal Sequestration of [3H]Amphetamine and [3H]Methylenedioxyamphetamine: Characterization Suggests the Presence of a Factor Responsible for Maintaining Sequestration

Robert Zaczek, Steven Culp, Errol B. De Souza

Journal:

Journal of Neurochemistry

Year:

1990

Language:

english

File:

PDF, 980 KB

english, 1990

42

Regional Distribution to Recovery of 5-HT Levels after Administration of “Atrophins” MDMA and D, L-Fenfluramine Stereospecificity and Comparison with 5,7-Dihydroxytryptamine

JOHN LEHMANN, ERROL B. DeSOUZA, STEVE CULP, ROBERT ZACZEK

Journal:

Annals of the New York Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 248 KB

english, 1992

43

Differential effects of DSP-4 on noradrenaline axons in cerebral cortex and hypothalamus may reflect heterogeneity of noradrenaline uptake sites

Robert Zaczek, Jean-Marc Fritschy, Steven Culp, Errol B. De Souza, Reinhard Grzanna

Journal:

Year:

1990

Language:

english

File:

PDF, 3.21 MB

english, 1990

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